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50 mOsm/kg (This is possible because these tubular segments are tight epithelia, and there is very little back-leak of sodium from interstitium to tubular lumen despite the large electrochemical gradient favoring diffusion) What happens when the collecting-duct system s water permeability is very high instead of very low As the hypo-osmotic fluid entering the collecting-duct system from the distal convoluted tubule flows through the cortical collecting ducts, water is rapidly reabsorbed This is because of the large difference in osmolality between the hypo-osmotic luminal fluid and the iso-osmotic (285 mOsm/ kg) interstitial fluid of the cortex In essence, the cortical collecting duct is reabsorbing the large volume of water that did not accompany solute reabsorption in the ascending limbs of Henle s loop and distal convoluted tubule In other words, the cortical collecting duct reverses the dilution carried out by the diluting segments.

Once the osmolality of the luminal fluid approaches that of the interstitial fluid, the cortical collecting duct then behaves analogously to the proximal tubule, reabsorbing approximately equal proportions of solute (mainly sodium chloride) and water The result is that the tubular fluid, which leaves the cortical collecting duct to enter the medullary collecting duct, is iso-osmotic compared with cortical plasma, and its volume is greatly reduced compared with the amount entering from the distal tubule In the medullary collecting duct, solute reabsorption continues but water reabsorption is proportionally even greater In other words, the tubular fluid becomes more and more hyperosmotic and reduced in volume in its passage through the medullary collecting ducts because the interstitial fluid of the medulla is very hyperosmotic, for reasons discussed later.

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How does ADH convert epithelial water permeability from very low to very high An alternative name for ADH is vasopressin, because the hormone can constrict arterioles and thus increase arterial blood pressure, but ADH s major renal effect is antidiuresis (ie, against a high urine volume ) In the absence of ADH, the water permeability of the cortical and outer medullary collecting duct is very low, and little if any water is reabsorbed from these segments, resulting in water diuresis On the other hand, in the presence of high plasma concentrations of ADH, the water permeability of all regions of the collecting ducts is great, and only a small volume of maximally hyperosmotic urine is excreted.

The tubular response to ADH is not all or none, however, but shows graded increases as the plasma concentration of ADH is increased over a certain range, thus permitting fine adjustments of collecting-duct water permeability and, hence, water reabsorption (The control of ADH secretion is described in 7) ADH acts in the collecting ducts on the principal cells, the same cells that reabsorb sodium (and, as is seen in 8, secrete potassium) The renal receptors for ADH (vasopressin type 2 receptors) are in the basolateral membrane of the principal cells and are different from the vascular receptors (vasopressin type 1) The binding of ADH by its receptors results in the activation of adenylate cyclase, which catalyzes the intracellular production of cyclic adenosine monophosphate This second messenger then induces, by a sequence of events, the migration of intracellular vesicles to, and their fusion with, the luminal membrane.

Recall from 4, this is one.

Then, continue as follows:

If a scheduled synchronization is in progress and a portable computer is switched from alternating current to battery power, you can have Windows XP Professional cancel synchronization. This might occur if scheduled synchronization starts on a docked portable computer that is using a wireless network connection and the user performs a hot undock. To stop scheduled synchronization when the computer is running on battery power 1. In All Programs, point to Accessories, and then click Synchronize. 2. In the Items to Synchronize dialog box, click Setup. 3. Click the Scheduled tab. 4. Click a scheduled task, and then click Edit. 5. On the Settings tab, under Power Management, select the Stop the task if battery mode begins check box.

CAPEX reduction is clear when building automation systems are reduced in numbers. CAPEX reduction in smart buildings is achieved primarily through vastly simplified inventories of spare parts. Reduction in spare parts also means a smaller

Places, see Finding My Network Places, opposite.)

Importing Data into SQL Server To import data into SQL Server, complete the following steps:

Your screen looks like this:

Figure 20-21.

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